Flexeril Cyclobenzaprine Hcl: Uses, Dosage, Side Effects, Interactions, Warning

However, it is important to note that animal studies cannot always predict the effects of a drug on human pregnancies. Furthermore, there is a lack of consensus among healthcare providers regarding the safety of Flexeril during pregnancy. Some may suggest taking other medications, while others may recommend discontinuation or restriction of the drug during pregnancy.

This drug has been shown to be excreted in rat milk and achieve concentrations in the milk which are 50% of those in the rat maternal plasma. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly).

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Some women may also experience nausea, vomiting, and headaches while taking the medication. Flexeril is usually given in 10 mg tablets up to three times daily 1. It is generally not considered addictive, but it may have side effects such as sleepiness and dizziness. These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine. FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward.

What should I watch for while using this medication?

Do not start, stop, or change the dosage of any medicines without your doctor’s approval. On the flip side, some women reported negative experiences with Flexeril while pregnant. One woman mentioned that she took Flexeril for back spasms during her third trimester and her baby was born with respiratory issues. Overall, it is important to weigh the potential risks and benefits of using Flexeril during pregnancy and to have open and honest discussions with your doctor. However, the use of Flexeril has been found to be safe under certain conditions.

  • Amitriptyline is a tricyclic antidepressant (TCA) and is used for treating depression.
  • It works by blocking pain sensations that are sent to your brain.
  • Research on the exact effects of consuming Cyclobenzaprine during delivery and breastfeeding is on (Burra, B., Datta, P., Rewers-Felkins, K., Baker, T. and Hale, T.W., 2019).

However, if you are a lactating woman, you might be concerned about the safety of taking Flexeril when breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Our goal is to provide you with the most relevant and current information.

Cyclobenzaprine warnings

Like any medication, Flexeril comes with potential side effects. These side effects can range from mild to severe, and it’s important to know what to look out for if you’re taking the medication during pregnancy. Common side effects of Flexeril include drowsiness, dizziness, dry mouth, and blurred vision.

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If you have questions about side effects, call your doctor. Overdose symptoms may include severe drowsiness, vomiting, fast heartbeats, tremors, agitation, or hallucinations. The recommended flexeril hydroxyzine interactions adult dose is 100 to 300 mg daily in divided doses or at bedtime. The initial dose is 50 to 100 mg at bedtime that may be increased by 25 or 50 mg at bedtime as needed.

Usually, doctors prescribe Flexeril to lactating women only after considering its benefits and side effects. Sometimes, muscle relaxants like cyclobenzaprine are used “off-label” to treat conditions they’re not approved for, such as fibromyalgia. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly).


In three of these studies there was a significantly greater improvement with FLEXERIL than with diazepam, while in the other studies the improvement following both treatments was comparable. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration. Seizures should be controlled with benzodiazepines or, if these are ineffective, other anticonvulsants (e.g. phenobarbital, phenytoin).